Preventing Puppy Diseases

September 18, 2020

The deaths of countless puppies might soon be prevented, thanks to a newly tested monoclonal antibody.

A study conducted by Kindred Biosciences has demonstrated 100 percent efficacy in the prevention of canine parvovirus (CPV), as well as a mortality benefit in the treated group, the company says.

In a randomized, blinded, study, half of a sample group received a placebo, while the other half were administered KIND-030, a monoclonal antibody that binds to portions of CPV and prevents it from entering cells.

None of the canines treated with the product developed the disease, KindredBio says, while all of the placebo-control dogs developed parvovirus infection as predefined in the study protocol.

“These positive study results provide hope for the first time to dogs exposed to this deadly disease,” says the company’s director of clinical development, Beth Kee, DVM.

CPV typically affects unvaccinated puppies younger than six months old, but it can occur in unvaccinated dogs of all ages. Further, it is the most significant and contagious viral cause of enteritis in dogs, especially puppies, with mortality rates as high as 91 percent.

Banfield Pet Hospital estimates there are approximately 250,000 parvo cases in the U.S. annually, excluding emergency hospitals, shelters, specialty hospitals, and undiagnosed cases, according to KindredBio. Additionally, the company says, BluePearl noted a 70 percent increase in cases at its hospitals throughout the COVID pandemic.

At this time, there are neither Food and Drug Administration- (FDA-) or United States Department of Agriculture- (USDA-) approved treatments for CPV nor any other available treatment, KindredBio says.

“There is no one solution to a disease as prevalent and fatal as canine parvovirus,” Dr. Kee says. “Veterinarians and their staff do the best they can with their current tools against parvovirus, which are mainly proper vaccination and, if exposed, supportive care and isolation. Our hope is that by providing veterinarians with a single tool addressing both prevention when exposed and treatment of parvovirus infection, we are at last providing a solution for this devastating disease.”

The antibody is currently being pursued for two indications in dogs: prophylactic therapy to prevent clinical signs of CPV infection and treatment of established parvovirus infection, with the announced results supporting the latter.

The study is expected to be complete by year-end with approval of the product candidate anticipated by early 2021. Regulatory approval and review timeline are subject to the typical risks inherent in such a process, KindredBio says.

  • Most Recent News

    Big Dogs Need Owners

    October 9, 2020

    When the shutdown orders took full effect, it became nearly impossible to find a small dog available for adoption as Southlanders sought furry companions. In many Southland shelters, only larger breeds remained available for adoption. Now Los Angeles Animal Service is touting the joys of big dogs while offering discounted adoption fees for larger breeds […]

    Read more

    Service Dog Walkathon

    October 9, 2020

    On Saturday, October 3, hundreds of walkers from across 15 states joined the path to bettering the world for children with autism and their families as part of BluePath Service Dogs’ fourth annual walkathon. The family-friendly fundraiser – this year held virtually – raised more than $120,000 to further BluePath’s mission of providing autism service […]

    Read more

    Service Dog In The Marching Band

    October 9, 2020

    In a year that is anything but normal, the Jones College Maroon Typhoon Marching Band has welcomed its first known service dog member this fall. Laurie, a 3-year-old golden retriever, is baritone saxophone player Sara-Beth McKellar’s service dog. The Vicksburg native was diagnosed with epilepsy as a sophomore in high school after her first seizure. […]

    Read more

    Church Blesses Animals

    October 9, 2020

    St. Mary’s Church of the Immaculate Conception in Port Jervis hosted a special outdoor service last Sunday afternoon to bless the community’s pets, animals and other living creatures. In keeping with current pandemic rules, pet owners wore masks, remained distant, and took part in praying for dogs, cats, turtles, and other pets and animals around […]

    Read more

    Police Welcomes New Canine

    October 9, 2020

    Young Kingston Police service dog Bask may look small, but his handler says his training and energy are proving that he’s up to fill the shoes of his predecessor. “I think he’s going to be a great little dog,” Const. Jeff Dickson said, looking down at his new partner. A partner that, wearing the right […]

    Read more

    Dog Park For Travelers

    October 9, 2020

    St. Petersburg is widely recognized as a dog-friendly city, and St. Pete-Clearwater International Airport is making sure its four-legged visitors and their humans feel welcome by rolling out the artificial turf carpet. With the completion of the airport’s parking and roadway project – part of a series of multi-million dollar improvements at the airport over the […]

    Read more

    Service Dog Helps Firefighters

    October 9, 2020

    Firefighters battling the Archie Creek and Thielsen fires have had some long, exhausting days. But for some, their troubles seemed to melt away once they got back to camp. Why? Meet Ralph Colombo. He hauls oversize loads. And joining Ralph is his service dog, Cowboy – the morale boosting, firefighting puppy. “He just keeps my […]

    Read more

    Pet Therapy Program

    October 9, 2020

    Saturday, October 10 is World Mental Health Day, which this year has a new sense of urgency for many. Covid-19 has taken a mental and emotional toll on healthcare workers across the U.S but there is a program boosting the spirits of doctors and nurses on the frontlines. At UC Irvine Medical Center in Southern […]

    Read more

    A Service Dogs Place

    October 9, 2020

    A new Pineville nonprofit that helps people with disabilities obtain service dogs has made its first match. The Saber Life Foundation was started in March by Danea Key and her husband Joel. They provide people with trained service dogs, paying 51 percent of the cost, with the client paying the other 49 percent. Service dogs […]

    Read more

    Dog Beating Cancer

    October 9, 2020

    A little over a year after a local dog was given only a few months to live after being diagnosed with bone cancer, she is still in remission and will be celebrated her twelfth birthday this month. Cocoa has been with her owner, Bucyrus resident Christie Auck, since she was nine-weeks-old. “On Aug. 18, 2019, […]

    Read more

    More Recent News